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Felix Kratz Selected Research

Prodrugs

1/2019Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound.
9/2014A clinical update of using albumin as a drug vehicle - a commentary.
1/2014A facile approach for dual-responsive prodrug nanogels based on dendritic polyglycerols with minimal leaching.
9/2012Development of novel bisphosphonate prodrugs of doxorubicin for targeting bone metastases that are cleaved pH dependently or by cathepsin B: synthesis, cleavage properties, and binding properties to hydroxyapatite as well as bone matrix.
9/2012Comparative evaluation of the biological properties of reducible and acid-sensitive folate prodrugs of a highly potent doxorubicin derivative.
7/2012Clinical impact of serum proteins on drug delivery.
7/2012Zosuquidar and an albumin-binding prodrug of zosuquidar reverse multidrug resistance in breast cancer cells of doxorubicin and an albumin-binding prodrug of doxorubicin.
2/2012A thermally responsive biopolymer conjugated to an acid-sensitive derivative of paclitaxel stabilizes microtubules, arrests cell cycle, and induces apoptosis.
1/2012Impact of albumin on drug delivery--new applications on the horizon.
12/2010Development of a novel prodrug of paclitaxel that is cleaved by prostate-specific antigen: an in vitro and in vivo evaluation study.
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Felix Kratz Research Topics

Disease

42Neoplasms (Cancer)
01/2021 - 12/2002
11Breast Neoplasms (Breast Cancer)
09/2014 - 06/2007
10Carcinoma (Carcinomatosis)
12/2010 - 10/2005
7Hepatocellular Carcinoma (Hepatoma)
02/2017 - 06/2004
5Sarcoma (Soft Tissue Sarcoma)
09/2014 - 06/2007
3Hyperthermia
10/2012 - 02/2012
3Cardiotoxicity
07/2012 - 02/2007
3Prostatic Neoplasms (Prostate Cancer)
12/2010 - 03/2008
2Pancreatic Neoplasms (Pancreatic Cancer)
09/2014 - 07/2012
2Neoplasm Metastasis (Metastasis)
09/2012 - 12/2010
2Lung Neoplasms (Lung Cancer)
09/2012 - 06/2006
2Rheumatoid Arthritis
07/2012 - 01/2012
2Small Cell Lung Carcinoma (Small Cell Lung Cancer)
08/2007 - 06/2007
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
09/2014
1Body Weight (Weight, Body)
01/2013
1Body Weight Changes
01/2013
1Hepatitis
07/2012
1Communicable Diseases (Infectious Diseases)
01/2012
1Brain Neoplasms (Brain Tumor)
01/2012
1Stomach Neoplasms (Stomach Cancer)
01/2012
1Mast Cell Activation Disorders (Mast-Cell Disease)
01/2011

Drug/Important Bio-Agent (IBA)

34Doxorubicin (Adriamycin)FDA LinkGeneric
01/2021 - 12/2002
26ProdrugsIBA
01/2019 - 12/2002
22AlbuminsIBA
06/2019 - 07/2002
18Pharmaceutical PreparationsIBA
01/2019 - 12/2002
12AcidsIBA
01/2019 - 12/2002
8Human Serum AlbuminFDA LinkGeneric
09/2014 - 06/2004
7Peptides (Polypeptides)IBA
01/2012 - 09/2003
6DOXO-EMCHIBA
09/2014 - 02/2007
6Paclitaxel (Taxol)FDA LinkGeneric
09/2014 - 12/2010
6Antineoplastic Agents (Antineoplastics)IBA
07/2012 - 12/2004
5PolymersIBA
11/2017 - 06/2006
5Proteins (Proteins, Gene)FDA Link
08/2014 - 11/2008
5Cathepsin BIBA
09/2012 - 05/2007
4Albumin-Bound PaclitaxelFDA Link
09/2014 - 12/2008
4HydrazonesIBA
02/2012 - 09/2003
4Prostate-Specific Antigen (Semenogelase)IBA
12/2010 - 10/2005
3Matrix Metalloproteinases (MMPs)IBA
01/2021 - 07/2003
3Elastin-Like PolypeptidesIBA
01/2021 - 07/2012
3Drug CarriersIBA
01/2019 - 10/2009
3Folic Acid (Vitamin M)FDA LinkGeneric
08/2014 - 11/2008
3LigandsIBA
08/2014 - 01/2008
3Sulfhydryl Compounds (Thiols)IBA
03/2008 - 12/2002
3Peptide Hydrolases (Proteases)FDA Link
08/2007 - 10/2006
3Asialoglycoprotein ReceptorIBA
08/2006 - 06/2004
2EnzymesIBA
01/2021 - 01/2008
26-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA
01/2021 - 10/2012
2IntegrinsIBA
11/2017 - 07/2008
2polyglycerolIBA
08/2013 - 05/2011
2Cytostatic AgentsIBA
12/2012 - 08/2007
2CamptothecinIBA
07/2012 - 05/2007
2LuciferasesIBA
12/2010 - 03/2008
2Serine Proteases (Serine Protease)IBA
03/2008 - 10/2005
2arginylarginine (Arg-Arg)IBA
11/2007 - 10/2006
22- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA
11/2007 - 05/2007
2alanylphenylalanine (Ala-Phe)IBA
11/2007 - 08/2007
2AnthracyclinesIBA
08/2007 - 06/2007
2Methotrexate (Mexate)FDA LinkGeneric
08/2007 - 07/2002
2Daunorubicin (Cerubidine)FDA LinkGeneric
06/2006 - 09/2003
1auristatinIBA
01/2019
1Prostaglandins AIBA
11/2017
1Sorafenib (BAY 43-9006)FDA Link
02/2017
1Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric
08/2014
1Pyruvic Acid (Pyruvate)IBA
08/2014
1Oxidoreductases (Dehydrogenase)IBA
08/2014
1NanogelsIBA
01/2014
1ErbB Receptors (EGF Receptor)IBA
08/2013
1Immunoconjugates (Immunoconjugate)IBA
08/2013
1Single-Chain AntibodiesIBA
08/2013
1Cell-Penetrating PeptidesIBA
10/2012
1Durapatite (Hydroxylapatite)IBA
09/2012
1Diphosphonates (Bisphosphonates)IBA
09/2012
1ApatitesIBA
09/2012
1Carrier Proteins (Binding Protein)IBA
07/2012
1Ethanol (Ethyl Alcohol)IBA
07/2012
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/2012
1Transferrin (beta 2 Transferrin)IBA
07/2012
1cremophorIBA
07/2012
1Proteasome InhibitorsIBA
07/2012
1thiazolyl blueIBA
07/2012
1benzyloxycarbonylleucyl-leucyl-leucine aldehydeIBA
07/2012
1Exenatide (Byetta)FDA Link
01/2012
1LiraglutideFDA Link
01/2012
1Hypoglycemic Agents (Hypoglycemics)IBA
01/2012
1Insulin (Novolin)FDA Link
01/2012
1Fatty Acids (Saturated Fatty Acids)IBA
01/2012
1Insulin Detemir (Levemir)FDA Link
01/2012
1Fluorescein (Funduscein)FDA LinkGeneric
01/2012
1technetium Tc 99m nanocolloidIBA
01/2012
1Omalizumab (Xolair)FDA Link
01/2011
1Monoclonal AntibodiesIBA
01/2011
1anti-IgE antibodiesIBA
01/2011
1Taxoids (Taxanes)IBA
12/2010
1tyrosyltyrosine (Tyr-Tyr)IBA
08/2010
14-azidobenzylcarazolol (pABC)IBA
08/2010
1arginyl-glycyl-aspartic acidIBA
02/2009

Therapy/Procedure

12Drug Therapy (Chemotherapy)
01/2021 - 12/2002
7Therapeutics
11/2017 - 09/2003
3Intravenous Administration
03/2008 - 12/2002
1Induced Hyperthermia (Thermotherapy)
07/2012